Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Neurol. 1995 Sep;13(2):161-3.

Expression of beta-amyloid precursor protein in axons of periventricular leukomalacia brains.

Author information

  • 1Department of Mental Retardation and Birth Defect Research, National Center for Neurology and Psychiatry, Tokyo, Japan.

Abstract

Human beta-amyloid precursor protein immunoreactivity was demonstrated in axonal swellings (spheroids) around periventricular leukomalacia (PVL) of neonates. Immunoreactive axons were found at the early, but not late stage of PVL. beta-Amyloid precursor protein immunoreactivity was homogeneous in damaged axons at the early stage of PVL manifesting microglial activation, concentrated at the center of axonal swellings at the subsequent stage manifesting astrogliosis, and undetectable at the terminal stage of cavitation or neovasculation. Immunostaining for beta-amyloid precursor protein was useful in localizing PVL lesions at their early stages.

PMID:
8534283
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk