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    J Pharm Sci. 1977 Apr;66(4):586-7.

    Cytotoxic and tumor inhibitory agent from Polygala macradenia Gray (Polygalaceae): 4'-demethyldeoxypodophyllotoxin.

    Hoffmann JJ, Wiedhopf RM, Cole JR.

    Abstract

    The chloroform fraction of Polygala macradenia exhibited activity against the P-388 lymphocytic leukemia and human epidermoid carcinoma of the nasopharynx test systems. The constituent responsible for this activity was a lignan, 4'-demethyldeoxypodophyllotoxin (C21H20O7). The identity was proven by elemental analysis; PMR, IR, mass spectrometric, and melting-point determinations; and preparation of a derivative.

    PMID:
    853371
    [PubMed - indexed for MEDLINE]

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