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Trends Biochem Sci. 1995 Oct;20(10):402-5.

Nucleotide excision repair and the link with transcription.

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  • 1MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, UK.


Nucleotide excision repair (NER) uses the products of about 30 genes to remove a damage-containing oligonucleotide from cellular DNA. The transcription factor TFIIH is an essential component of NER. In man, defects in NER can result in three distinct genetic disorders, whose features can be ascribed to abnormalities in DNA repair or transcription.

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