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Trends Biochem Sci. 1995 Oct;20(10):397-401.

Mismatch repair: mechanisms and relationship to cancer susceptibility.

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  • 1Division of Human Cancer Genetics, Dana-Farber Cancer Institute, Boston, MA 02115, USA.


DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.

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