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Gene. 1995 Dec 1;166(1):121-6.

Identification of Streptomyces olivaceus Tü 2353 genes involved in the production of the polyketide elloramycin.

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  • 1Biologisches Institut, Universität Tübingen, Germany.


The genes for the production of elloramycin (ELM) from Streptomyces olivaceus (So) Tü2353 were cloned using a polyketide synthase gene probe from the tetracenomycin pathway. A cosmid clone (16F4) isolated from a gene library of So Tü2353 conferred tetracenomycin C and ELM resistance to S. lividans TK64 and complemented a mutation in So Tü2353R. Introduction of cosmid 16F4 into S. lividans TK64 resulted in the production of 8-demethyl-tetracenomycin C, an intermediate of ELM biosynthesis.

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