Curr Opin Struct Biol. 1995 Aug;5(4):521-7.

Structure, function, and membrane integration of defensins.

Source

Department of Physiology and Biophysics, University of California, Irvine 92717-4560, USA.

Abstract

Defensins comprise a structural class of small cationic peptides that exert broad-spectrum antimicrobial activities through membrane permeabilization. Their predominantly beta-sheet structure, stabilized by three disulfide bonds, distinguishes them from other antimicrobial peptides which typically form amphiphilic helices. Defensins bind to membranes electrostatically and subsequently form apparently multimeric pores. Recent structural and biophysical studies are beginning to provide insights into the process of permeabilization.

PMID:: 8528769; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Defensins. [Eur J Haematol. 1990]
Review Defensins.
Ganz T, Selsted ME, Lehrer RI. Eur J Haematol. 1990 Jan; 44(1):1-8.
Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. [Science. 1991]
Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.
Hill CP, Yee J, Selsted ME, Eisenberg D. Science. 1991 Mar 22; 251(5000):1481-5.
Review Defensins and other endogenous peptide antibiotics of vertebrates. [J Leukoc Biol. 1995]
Review Defensins and other endogenous peptide antibiotics of vertebrates.
Martin E, Ganz T, Lehrer RI. J Leukoc Biol. 1995 Aug; 58(2):128-36.
Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. [J Biol Chem. 1993]
Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.
Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS. J Biol Chem. 1993 Mar 25; 268(9):6641-8.
Review Defensins: antimicrobial and cytotoxic peptides of mammalian cells. [Annu Rev Immunol. 1993]
Review Defensins: antimicrobial and cytotoxic peptides of mammalian cells.
Lehrer RI, Lichtenstein AK, Ganz T. Annu Rev Immunol. 1993; 11:105-28.

See reviews... See all...

Cited by 45 PubMed Central articles

Bile salts induce resistance to polymyxin in enterohemorrhagic Escherichia coli O157:H7. [J Bacteriol. 2011]
Bile salts induce resistance to polymyxin in enterohemorrhagic Escherichia coli O157:H7.
Kus JV, Gebremedhin A, Dang V, Tran SL, Serbanescu A, Foster DB. J Bacteriol. 2011 Sep; 193(17):4509-15. Epub 2011 Jul 1.
C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. [Antimicrob Agents Chemother. 2...]
C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus.
Singh M, Mukhopadhyay K. Antimicrob Agents Chemother. 2011 May; 55(5):1920-9. Epub 2011 Jan 31.
HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells. [Virology. 2011]
HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells.
Tugizov SM, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. Virology. 2011 Jan 20; 409(2):211-22. Epub 2010 Nov 5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Domains
Conserved Domain Database (CDD) records that cite the current articles. Citations are from the CDD source database records (PFAM, SMART).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structure, function, and membrane integration of defensins.
Structure, function, and membrane integration of defensins.
Curr Opin Struct Biol. 1995 Aug ;5(4):521-7.

PubMed
Epidemiology of AIDS dementia complex in Europe. AIDS in Europe Study Group.
Epidemiology of AIDS dementia complex in Europe. AIDS in Europe Study Group.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jan 1 ;11(1):39-44.

PubMed
Transformation of fish cells and embryos.
Transformation of fish cells and embryos.
Methods Mol Biol. 1995 ;48:245-51.

PubMed
The fragile X mental retardation protein is associated with ribosomes.
The fragile X mental retardation protein is associated with ribosomes.
Nat Genet. 1996 Jan ;12(1):91-3.

PubMed
A mutation in the gene encoding the alpha 2 chain of the fibril-associated colla...
A mutation in the gene encoding the alpha 2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2).
Nat Genet. 1996 Jan ;12(1):103-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Structure, function, and membrane integration of defensins.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 45 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information