Eur J Clin Pharmacol. 1977 Mar 11;11(3):199-201.

Clozapine-induced agranulocytosis: a situation report up to August 1976.

Abstract

The frequency of agranulocytosis in association with clozapine therapy has been estimated and compared with data reported for phenothiazine-induced agranulocytosis. Apart from the "epidemic" in Finland, where the frequency was 21 times that in other countries, there is no evidence that clozapine-related agranulocytosis is more common than the phenothiazine-related disorder. Furthermore, results are given to show that strict adherence to precautionary measure (e.g. weekly blood counts) reduces the mortality-rate of this condition.

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Agranulocytosis in patients treated with clozapine. A study of the Finnish epidemic. [Acta Psychiatr Scand. 1977]
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Amsler HA, Teerenhovi L, Barth E, Harjula K, Vuopio P. Acta Psychiatr Scand. 1977 Oct; 56(4):241-8.
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Clozapine-induced agranulocytosis: a situation report up to August 1976.

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