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J Virol. 1996 Jan;70(1):663-6.

bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation.

Author information

  • 1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706, USA.

Abstract

We previously demonstrated that expression of bcl-2 in Madin-Darby canine kidney (MDCK) cells blocks influenza virus-induced apoptosis and DNA fragmentation. We show here that expression of bcl-2 also reduces the level of infectious virus production and the spread of virus in MDCK cell cultures infected at a low multiplicity of infection. This effect is associated with modified glycosylation of the hemagglutinin protein.

PMID:
8523590
[PubMed - indexed for MEDLINE]
PMCID:
PMC189863
Free PMC Article
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