The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins

Cell Growth Differ. 1995 Sep;6(9):1193-8.

Abstract

The BTB/POZ domain defines a newly characterized protein-protein interaction interface. It is highly conserved throughout metazoan evolution and generally found at the NH2 terminus of either actin-binding or, more commonly, nuclear DNA-binding proteins. By mediating protein binding in large aggregates, the BTB/POZ domain serves to organize higher order macromolecular complexes involved in ring canal formation or chromatin folding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatin / metabolism
  • DNA-Binding Proteins / metabolism*
  • Drosophila
  • Microfilament Proteins / metabolism*
  • Molecular Sequence Data
  • Nuclear Proteins / metabolism*
  • Protein Structure, Tertiary*
  • Sequence Homology, Amino Acid
  • Structure-Activity Relationship
  • Viral Proteins / metabolism*
  • Zinc Fingers*

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Microfilament Proteins
  • Nuclear Proteins
  • Viral Proteins