Lancet. 1979 Mar 17;1(8116):578-80.

Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

Grundke-Iqbal I, Johnson AB, Wisniewski HM, Terry RD, Iqbal K.

Abstract

Antiserum against normal human neurotubules purified by in-vitro assembly precipitated both neurotubules and a polypeptide isolated from Alzheimer neurofibrillary tangles in Ouchterlony double-diffusion tests. The antiserum specifically labelled neurofibrillary tangles, in isolated neurons by immunofluorescence and in tissue sections by the peroxidase-antiperoxidase technique. These results indicate that neurofibrillary tangles in Alzheimer's disease probably originate from neurotubules.

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Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

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