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FEBS Lett. 1993 Jun 28;325(1-2):63-6.

The humoral antibacterial response of Drosophila.

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  • 1Laboratoire de Biologie Générale, Université Louis Pasteur, URA 1490 du CNRS, Strasbourg, France.


Drosophila, like other insects, responds to the injection of bacteria by the rapid and transient synthesis of a battery of potent antibacterial peptides. Only a few of these peptides have been fully characterized to date. We review our recent data on the control of the expression of a gene encoding one of the induced peptides, i.e. diptericin. Our data highlight the role of proximal cis-regulatory motifs similar to regulatory elements binding NF-kappa B and NF-IL6 in promoters of some immune genes of mammals. We argue that the Drosophila host defense is homologous to the mammalian acute phase response.

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