Format

Send to:

Choose Destination
See comment in PubMed Commons below
Semin Cancer Biol. 1993 Apr;4(2):73-83.

DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces.

Author information

  • 1Division of Molecular and Cellular Biology, Lawrence Berkeley Laboratory, Berkeley, CA 94720.

Abstract

The yeast Saccharomyces provides a powerful system for investigating the biological effects of ionizing radiation, and studies have identified double-strand breaks in DNA as probably of critical importance in determining lethality. These breaks are normally repaired by a recombinational mechanism, but in the absence of repair a single break may be lethal to the cell. Genetic and molecular analysis of the eight genes known as RAD50 to RAD57 has revealed much about recombinational repair. These genes are also of central importance in other processes including meiosis and may be of general significance in understanding radiation responses in eukaryotes.

PMID:
8513150
[PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Molecular Biology Databases

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk