Abstract
Epidural injections of a 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior-horn cells of the spinal cord.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Acute Disease
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Adult
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Aged
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Analgesia / methods*
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Chronic Disease
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Epidural Space / drug effects
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Female
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Fractures, Bone / complications
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Humans
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Injections
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Male
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Middle Aged
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Morphine / administration & dosage*
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Pain / etiology
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Pain, Intractable / drug therapy*
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Pain, Postoperative / drug therapy*
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Receptors, Opioid / drug effects
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Substantia Gelatinosa / drug effects
Substances
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Receptors, Opioid
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Morphine