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    Endocrinology. 1993 Jun;132(6):2484-90.

    Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.

    Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A.

    University of Oxford, Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital, Headington, United Kingdom.

    We report that human myometrium contains G alpha i1, G alpha i3, and G alpha q, and G alpha 11, which are expressed at similar levels in tissues from pregnant and nonpregnant women. G alpha i2 is also expressed, but at a slightly reduced level, in tissue taken from pregnant compared to nonpregnant donors. The major finding of this investigation is the substantial increase in G alpha s expression in pregnant myometrium. The increase in G alpha s levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy.

    PMID: 8504751 [PubMed - indexed for MEDLINE]

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