Identification and expression of G-proteins in hum...[Endocrinology. 1993]

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1: Endocrinology. 1993 Jun;132(6):2484-90. Links

Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.

Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A.

University of Oxford, Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital, Headington, United Kingdom.

We report that human myometrium contains G alpha i1, G alpha i3, and G alpha q, and G alpha 11, which are expressed at similar levels in tissues from pregnant and nonpregnant women. G alpha i2 is also expressed, but at a slightly reduced level, in tissue taken from pregnant compared to nonpregnant donors. The major finding of this investigation is the substantial increase in G alpha s expression in pregnant myometrium. The increase in G alpha s levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy.

PMID: 8504751 [PubMed - indexed for MEDLINE]

Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturition. [J Clin Endocrinol Metab. 1994]
Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium. [Eur J Pharmacol. 1994]
Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. [Am J Physiol. 1997]
ReviewParturition: activation of stimulatory pathways or loss of uterine quiescence? [Adv Exp Med Biol. 1995]
ReviewMechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium. [Adv Exp Med Biol. 1995]

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Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.

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