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Biochemistry. 1993 Jun 1;32(21):5497-502.

Three small ribooligonucleotides with specific arginine sites.

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  • 1Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347.

Abstract

Arginine-binding RNA motifs are important to protein-RNA interaction and perhaps also for Archean biochemistry. Selection-amplification was used to isolate three RNAs that are eluted by free arginine from an L-arginine affinity column (Kd approximately 0.2-0.4 mM). The binding sites contain specific internal and bulge loops, whose sequences can include arginine coding triplets. Binding is highly specific for arginine, but all three motifs, like the self-splicing group I intron, also bind guanosine 5'-monophosphate. One site is stereoselective, somewhat preferring D-arginine.

PMID:
8504070
[PubMed - indexed for MEDLINE]

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