My NCBI | Sign In
RSS Settings
  • Search:

Display Settings:

Format

Send to:

Choose Destination

    Biochem Biophys Res Commun. 1993 May 28;193(1):47-53.

    Extrahepatic, differential expression of four classes of human alcohol dehydrogenase.

    Engeland K, Maret W.

    Center for Biochemical and Biophysical Sciences and Medicine Harvard Medical School, Boston, MA 02115.

    The amounts of mRNA expressed for different alcohol dehydrogenase (ADH) classes were determined in human tissues by Northern hybridization. ADH classes I, II, and III were expressed in all tissues. The mRNAs were highest for class I ADHs, with particularly strong signals in liver, lung, ileum, colon, and uterus. For class II ADH, such a wide tissue distribution had not been recognized previously. Expression of class III ADH was highest in testis, followed by uterus, colon, and ileum. The amounts of class I and III ADH mRNAs varied significantly, indicating that tissue-specific factors modulate the expression of these enzymes above a basal level. Class V ADH (ADH6) was not detected in any of the tissues, including stomach. This suggests that class V ADH is not identical with human stomach sigma-ADH (class IV). The results support the general proposition that ADHs are not restricted to liver and have functions other than those in ethanol oxidation.

    PMID: 8503936 [PubMed - indexed for MEDLINE]

    Publication Types, MeSH Terms, Substances

    Publication Types:

    MeSH Terms:

    Substances:

    LinkOut - more resources

    Full Text Sources:

    Libraries:

    Supplemental Content

    Click here to read

    Related articles

    All links from this record

    • Related Articles

      Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.

    • Gene

      Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.

    • HomoloGene

      HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.

    • Nucleotide (RefSeq)

      NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.

    • Nucleotide (Weighted)

      Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.

    • Protein (RefSeq)

      NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.

    • Protein (Weighted)

      Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.

    • Substance (MeSH Keyword)

      PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

    • Taxonomy via GenBank

      Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).

    • UniGene

      UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.

    • GEO Profiles

      Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.

    Recent activity