How sound is the double-blind design for evaluatin...[J Nerv Ment Dis. 1993]

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1: J Nerv Ment Dis. 1993 Jun;181(6):345-50.Links

How sound is the double-blind design for evaluating psychotropic drugs?

Fisher S, Greenberg RP.

Department of Psychiatry, State University of New York Health Science Center, Syracuse 13210.

Sufficient data have accumulated to raise serious doubts about the integrity of the double-blind design that is presumed to shield psychotropic drug trials from bias and expectations. A major deficit in most drug trials has been the use of inert rather than active placebos. The deficiencies of the double-blind paradigm call for a questioning stance with respect to previous studies of psychotropic drug efficacy. Various possible ways of strengthening the double-blind paradigm are reviewed.

PMID: 8501455 [PubMed - indexed for MEDLINE]

Placebo use in clinical trials on psychotropic drugs in France. [Neuropsychobiology. 1983]
ReviewPlacebos, drug effects, and study design: a clinician's guide. [Am J Psychiatry. 1999]
[Principles and regulations for clinical pilot studies on psycholeptic drugs (author's transl)] [Arzneimittelforschung. 1978]
Designing drug efficacy trials in the treatment of cocaine abuse. [J Nerv Ment Dis. 1991]
ReviewPlacebo in the investigation of psychotropic drugs, especially antidepressants. [Sci Eng Ethics. 2004]

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How sound is the double-blind design for evaluating psychotropic drugs?

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