The effect of epitestosterone on the plasma levels of LH and FSH in ovariectomized immature rats

M Bicíková; R Kanceva; O Lapcík; M Hill; L Stárka

doi:10.1016/0960-0760(93)90349-2

The effect of epitestosterone on the plasma levels of LH and FSH in ovariectomized immature rats

J Steroid Biochem Mol Biol. 1993 Apr;45(4):321-4. doi: 10.1016/0960-0760(93)90349-2.

Authors

M Bicíková¹, R Kanceva, O Lapcík, M Hill, L Stárka

Affiliation

¹ Institute of Endocrinology, Prague, Czech Republic.

PMID: 8499340
DOI: 10.1016/0960-0760(93)90349-2

Abstract

Immature ovariectomized female rats primed with estradiol or without estrogen priming were treated with epitestosterone i.p. After 7 h blood was collected and LH and FSH levels were determined. The dose-response relationship was a biphasic one. LH and less markedly FSH levels decreased under epitestosterone treatment with doses up to 10 mg, whereas at higher doses an increase of gonadotrophins was observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dose-Response Relationship, Drug
Epitestosterone / administration & dosage
Epitestosterone / pharmacology*
Estradiol / pharmacology
Female
Follicle Stimulating Hormone / blood*
Injections, Intraperitoneal
Luteinizing Hormone / blood*
Ovariectomy
Rats
Rats, Wistar
Receptors, Estrogen / drug effects

Substances

Receptors, Estrogen
Epitestosterone
Estradiol
Luteinizing Hormone
Follicle Stimulating Hormone