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Pediatr Neurol. 1993 Mar-Apr;9(2):131-3.

Predictive value of placebo methylphenidate.

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  • 1Hannah Khoushy Child Development Center, Bnai Zion Medical Center, Haifa, Israel.


The effects of methylphenidate in 20 children with attention-deficit disorder between the ages of 7 and 12 years were assessed in a double-blind, placebo/drug counterbalanced study. Measures of outcome included the Teacher Rating Scale and Abbreviated Parent Rating Scale: digits, words, and visual sequencing; motor control; and a maze test. The Teacher Rating Scale placebo-drug difference correlated more significantly with the outcome measures than the baseline-drug difference. The study underlines the validity of a multimeasure placebo/drug trial in evaluating the efficacy of methylphenidate in children with attention-deficit disorder.

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