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Am J Med Genet. 1993 Apr 1;46(1):98-103.

Method for sequential staining of GTL-banded metaphases with fluorescent-labeled chromosome-specific paint probes.

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  • 1Section of Laboratory Genetics, Mayo Clinic, Rochester, Minnesota 55905.


We describe a method for use of fluorescent-labeled whole chromosome-specific paint probes on GTL-banded metaphases to utilize the combined potential of these techniques for defining chromosome abnormalities. The efficacy of this method was tested on 6 cases involving different chromosome abnormalities and various tissues, including blood, amniotic fluid, skin fibroblasts, and bone marrow.

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