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Biochem Mol Biol Int. 1993 Jan;29(1):63-7.

Effects of guanidine hydrochloride on catalytic efficiency of glycine amidinotransferase of rat.

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  • 1Department of Zoology, Sri Venkateswara University, Tirupati, India.


Guanidine-induced alterations in substrate-dependent kinetics of glycine amidinotransferase (GAT) have been investigated in homogenates of rat kidney. Guanidine hydrochloride (GuHCl) induced a mixed type of inhibition by decreasing the maximal velocity (Vmax) and increasing the Michaelis-Menten constant (Km). The finding of a value of Ki smaller than that of Ki' denoted that the inhibition of GAT may be due to decreased E to S affinity rather than to reduction in the active site density of the enzyme.

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