Nucl Med Biol. 1993 Apr;20(3):359-62.

Evaluation of [11C]thymidine for measurement of cell proliferation in fast dividing tissues.

Poupeye EM, Goethals PP, Dams RF, De Leenheer AP, van Eijkeren ME.

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Laboratoria voor Medische Biochemie en voor Klinische Analyse, Rijksuniversiteit Gent, Belgium.

Abstract

The purpose of this study was to investigate the possibility of using [11C]thymidine as a tumor marker for positron emission tomography studies. Biodistribution studies were set up to investigate the in vivo behavior of [11C]thymidine. Simultaneously, the DNA incorporation in fast dividing tissues and catabolism was studied. Our results confirm that [11C]thymidine can be used for detection of cell proliferation by positron emission tomography. As such, it can produce supplementary information in cancer research.

PMID:: 8485496; [PubMed - indexed for MEDLINE]

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Evaluation of [11C]thymidine for measurement of cell proliferation in fast dividing tissues.

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