Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Vet Res. 1993 Apr;54(4):573-5.

Pharmacokinetics and concentrations of ceftiofur sodium in body fluids and endometrium after repeated intramuscular injections in mares.

Author information

  • 1Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.

Abstract

Each of 5 healthy mares was given 5 consecutive IM injections of ceftiofur sodium (2 mg/kg of body weight; 50 mg/ml) at 12-hour intervals. Ceftiofur concentrations were measured serially in serum, synovial fluid, peritoneal fluid, and urine, and were measured in CSF and endometrial tissue after the fifth dose. Mean elimination rate constant was 0.354 +/- 0.101 h-1 and elimination half-life was 2.49 +/- 0.49 hour. Mean serum ceftiofur concentrations peaked approximately 1 hour after each injection. The highest mean ceftiofur concentration was 5.09 micrograms/ml at 1 hour after the fifth dose for serum, 3.02 micrograms/ml at 2 hours after the fifth dose for synovial fluid, and 3.23 micrograms/ml at 4 hours after the fifth dose for peritoneal fluid. Mean urine concentrations reached 15.72 micrograms/ml at 1 hour after the fifth dose. Ceftiofur was not detected in CSF or endometrial tissue. None of the mares had adverse reactions to the drug.

PMID:
8484577
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk