Blutalkohol. 1993 Mar;30(2):96-105.

[Effect of Kava-Special Extract WS 1490 combined with ethyl alcohol on safety-relevant performance parameters].

[Article in German]

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TUV Rheinland, Prüfstelle für Medikamenteneinflüsse auf Verkehrs- und Arbeitssicherheit, Köln, Germany.

Abstract

The Kava-special extract WS 1490 (3 x 100 mg/d over 8 days) was tested in a placebo-controlled randomised double-blind study to establish whether it has any adverse effects on safety-related performance when administered together with ethyl alcohol (0.05% blood alcohol concentration). The study was carried out as a comparison of two independent groups each containing 10 male and 10 female healthy volunteers aged between 18 to 60 years (mean: 40.45 +/- 12.2 years). The batteries of performance tests consisted of seven procedures. It was conducted before treatment without alcohol as well as the 1st, 4th and 8th day of treatment together with alcohol. The results showed no negative multiplicative effects caused by the Kava-special extract WS 1490 together with alcohol. With the concentration test however there was a remarkable advantage of the WS 1490 group at the 4th day of treatment (p < 1%). The collection of well-being data as well as the description of adverse events proved WS 1490 to be well tolerated.

PMID:: 8481222; [PubMed - indexed for MEDLINE]

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