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Am J Psychiatry. 1993 May;150(5):810-2.

Ketoconazole administration in hypercortisolemic depression.

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  • 1Department of Psychiatry, University of California, San Francisco.


Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.

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