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Mol Gen Genet. 1993 Apr;238(1-2):33-7.

The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.

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  • 1Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406.

Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

PMID:
8479437
[PubMed - indexed for MEDLINE]

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