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    Hum Genet. 1993 Apr;91(3):278-80.

    Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter.

    Brüss M, Kunz J, Lingen B, Bönisch H.

    Institut für Pharmakologie und Toxikologie, Universität Bonn, Germany.

    The neuronal Na(+)- and Cl(-)-dependent transporter for the neurotransmitter noradrenaline (NA) is the primary target for the tricyclic antidepressant desipramine. The NA-transporter belongs to a new gene family of structurally related Na(+)- and Cl(-)-dependent neurotransmitter transporters. In this study, the chromosomal localization for the gene encoding the human NA-transporter (h-NAT) was determined. By hybridization of a panel of somatic cell hybrids and by fluorescent in situ hybridization to metaphase chromosomes, the hNAT gene was localized on chromosome 16q12.2. In addition, evidence is presented for an intron-exon structure of the gene.

    PMID: 8478011 [PubMed - indexed for MEDLINE]

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    • Desipramine (Norpramin®)

      Desipramine is used to treat depression. Desipramine is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed for mental...

    • Source: AHFS Consumer Medication Information

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