Ther Umsch. 1993 Mar;50(3):178-81.

[Beta-carbolines (harman/norharman) are increased in heroin dependent patients].

[Article in German]

Stohler R, Rommelspacher H, Ladewig D, Dammann G.

Source

Psychiatrische Universitätsklinik, Basel.

Abstract

Endogenous substances resulting from interactions between alcohol and possibly opioid metabolites and neurotransmitters (dopamine, indolamines) are mediators of the pathochemical process towards dependence. Beta-carbolines are increased in alcoholics and--according to our own results--in heroin-addicts. Still unclear is the impact of other psychopathological disturbances like states of anxiety or depression; unclear is also, if it has to be interpreted as state, trait or residual marker of the dependence syndrome.

PMID:: 8475471; [PubMed - indexed for MEDLINE]

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