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A radioimmunoassay of the 15-keto- metabolite of prostaglandin E2 has been developed. The details of the assay are described. Using unextracted plasma, serial measurements of 15-keto-PGE2 have been carried out every 15 minutes for 3 hours in 9 women ingesting 0.5 mg PGE2 oral tablets used for the induction of labour.
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