Sequence homologies between hsp60 and autoantigens. [Immunol Today. 1993]

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1: Immunol Today. 1993 Mar;14(3):115-8.Links

Sequence homologies between hsp60 and autoantigens.

Jones DB, Coulson AF, Duff GW.

Dept of Medicine, Arrowe Park Hospital, Liverpool, Merseyside, UK.

The human heat shock protein (hsp) 60 shares sequence homology with a wide range of autoantigens including those of insulin dependent diabetes mellitus, Hashimoto's thyroiditis, glomerulonephritis, scleroderma, pemphigoid, rheumatoid arthritis, multiple sclerosis, chronic active hepatitis, primary biliary cirrhosis and Addison's disease. Here we show the extent of this homology and suggest that it contributes to autoimmunity through cross-reactivity between hsp60 and tissue-specific proteins containing similar epitope motifs. Differences between individuals in MHC class II may influence the selection of a particular hsp60 epitope and the corresponding target antigen that gives rise to an autoimmune disease.

PMID: 8466626 [PubMed - indexed for MEDLINE]

ReviewHeat shock proteins in autoimmune diseases. [Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005]
Human thyroid autoantigens and proteins of Yersinia and Borrelia share amino acid sequence homology that includes binding motifs to HLA-DR molecules and T-cell receptor. [Thyroid. 2006]
Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis. [Hepatology. 1998]
Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus. [Immunol Lett. 2002]
ReviewInfection and molecular mimicry in autoimmune diseases of childhood. [Clin Exp Rheumatol. 1994]

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Sequence homologies between hsp60 and autoantigens.

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