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J Clin Pathol. 1993 Mar;46(3):204-7.

Expression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta.

Author information

  • 1Department of Pathology, University of Hong Kong, Queen Mary Hospital.

Abstract

AIMS:

To compare the expression of c-myc and c-fms proto-oncogenes in the placenta and hydatidiform mole.

METHODS:

Twelve hydatidiform moles and six induced abortion cases were collected. c-myc and c-fms proto-oncogene expression was analysed by northern blot hybridisation and immunohistochemical staining.

RESULTS:

The results of northern blot hybridisation analysis showed that c-fms was expressed more strongly in hydatidiform moles compared with normal placenta of similar gestational age. Moreover, c-fms mRNA concentrations increased with more advanced gestational age in moles but not in normal placentas. c-myc expression was very low in hydatidiform moles and normal placentas. Both oncogenes, however, had no direct correlation with the clinical course of the molar pregnancies.

CONCLUSION:

The difference in c-fms expression between hydatidiform moles and normal placentas suggests that c-fms may have a role in the development of molar pregnancies.

PMID:
8463412
[PubMed - indexed for MEDLINE]
PMCID:
PMC501170
Free PMC Article
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