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    Am J Hum Genet. 1993 Apr;52(4):767-76.

    Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.

    Source

    Department of Pathology, University of Cambridge, England.

    Abstract

    In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

    PMID:
    8460642
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1682078
    Free PMC Article

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