Green tobacco sickness (GTS) is an illness resulting from dermal exposure to dissolved nicotine from wet tobacco leaves; it is characterized by nausea, vomiting, weakness, and dizziness and sometimes fluctuations in blood pressure or heart rate (1-3). On September 14, 1992, the Occupational Health Nurses in Agricultural Communities (OHNAC) project of Kentucky* received reports of 27 cases of GTS. The cases occurred among tobacco harvesters who had sought treatment in several hospital emergency departments in south-central Kentucky during the preceding 2 weeks. This report summarizes the findings of the investigation of these cases.