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Fertil Steril. 1993 Apr;59(4):791-6.

Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle.

Author information

  • 1Department of Gynecology and Obstetrics, Stanford University Medical Center, California 94305-5317.

Abstract

OBJECTIVE:

To investigate the messenger ribonucleic acid (mRNA) expression of interleukin-1 (IL-1) type I receptor in the endometrial tissue of normal patients during the menstrual cycle.

DESIGN:

Prospective longitudinal study.

SETTING:

Department of Obstetrics and Gynecology, Stanford University Medical Center, Stanford, California.

PATIENTS:

Twenty fertile women between 19 and 41 years of age underwent hysterectomy for benign reasons (n = 9) and laparoscopy for tubal ligation (n = 11). In all cases, endometriosis was not visualized.

INTERVENTIONS:

Endometrial biopsy using the Novak curette was obtained at the time of surgery.

MAIN OUTCOME MEASURE:

Total RNA extracted from unfractioned endometrial tissue was analyzed on Northern blots by using specific complementary deoxyribonucleic acid probes.

RESULTS:

We found IL-1 type I receptor mRNA expression in endometrial tissue throughout the entire menstrual cycle. However, IL-1 type I receptor mRNA levels were significantly higher during both early and late luteal phases than follicular and midluteal phases.

CONCLUSIONS:

Our results demonstrate the presence of the IL-1 system in the human endometrium and that the receptor is regulated throughout the menstrual cycle with a 4.1-fold increased expression of the IL-1 receptor gene in the early luteal phase compared with preovulatory endometrium.

PMID:
8458498
[PubMed - indexed for MEDLINE]
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