Comparative toxicity and pathology associated with administration of recombinant IL-2 to animals

Int Rev Exp Pathol. 1993:34 Pt A:57-77.

Authors

T D Anderson¹, T J Hayes, G D Powers, M K Gately, R Tudor, A Rushton

Affiliation

¹ Department of Toxicology and Pathology, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.

PMID: 8454417

No abstract available

Publication types

Comparative Study
Review

MeSH terms

Anemia, Hemolytic / chemically induced
Anemia, Hemolytic / pathology
Animals
Chemical and Drug Induced Liver Injury / etiology
Female
G(M1) Ganglioside / immunology
Hepatomegaly / chemically induced
Hepatomegaly / pathology
Immunization, Passive
Inflammation / chemically induced
Inflammation / pathology
Interleukin-2 / administration & dosage
Interleukin-2 / toxicity*
Killer Cells, Lymphokine-Activated / drug effects
Killer Cells, Lymphokine-Activated / pathology
Macaca fascicularis
Male
Mice
Mice, Inbred C57BL
Mice, SCID
Pulmonary Edema / chemically induced
Pulmonary Edema / pathology
Pulmonary Eosinophilia / chemically induced
Pulmonary Eosinophilia / pathology
Rats
Receptors, Interleukin-1 / immunology
Recombinant Proteins / administration & dosage
Recombinant Proteins / toxicity
Severe Combined Immunodeficiency / therapy
Splenomegaly / chemically induced
Splenomegaly / pathology
Tumor Necrosis Factor-alpha / immunology
Viscera / pathology

Substances

Interleukin-2
Receptors, Interleukin-1
Recombinant Proteins
Tumor Necrosis Factor-alpha
G(M1) Ganglioside
asialo GM1 ganglioside