Bactericidal/permeability increasing protein and h...[Curr Opin Immunol. 1993]

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1: Curr Opin Immunol. 1993 Feb;5(1):103-7.Links

Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin.

Elsbach P, Weiss J.

Department of Medicine, New York University School of Medicine, New York 10016.

The bactericidal/permeability increasing protein is a major element in the host defense against Gram-negative bacteria and endotoxin, acting intracellularly in the polymorphonuclear leukocyte. As an isolated protein, bactericidal/permeability increasing protein also acts as an extracellular bactericidal and endotoxin-neutralizing agent and, when injected, protects animals against lethal effects of Gram-negative bacteria and endotoxin.

PMID: 8452666 [PubMed - indexed for MEDLINE]

ReviewThe bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. [Immunobiology. 1993]
Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteria. [J Clin Invest. 1992]
ReviewBactericidal permeability-increasing protein in host defence against gram-negative bacteria and endotoxin. [Ciba Found Symp. 1994]
Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. [J Immunol. 1990]
Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. [Pediatrics. 1999]

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Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin.

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