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Am J Perinatol. 1993 Jan;10(1):12-3.

Trisomy 21 presented as a transient unilateral pleural effusion at 18 weeks' gestation.

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  • 1Department of Obstetrics and Gynecology, Strong Memorial Hospital, University of Rochester School of Medicine and Dentistry, NY 14642-8668.


We describe a rare case in which a unilateral fetal pleural effusion was noted at 18 weeks' gestation with subsequent spontaneous resolution occurring 1 week later. Amniocentesis revealed a trisomy 21 karyotype. Chromosomal analysis may be indicated in cases in which accumulation of fluid in fetal serous cavities has spontaneously resolved.

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