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J Pediatr. 1993 Mar;122(3):416-9.

Elevated serum aminotransferase activity as an early manifestation of gluten-sensitive enteropathy.

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  • 1Department of Pediatrics, Pediatric Gastroenterology and Hepatology, II Faculty of Medicine, University of Naples, Italy.


Six children in whom long-standing hypertransaminasemia of unknown cause led to an initial diagnosis of chronic or protracted cryptogenic hepatitis were found to have asymptomatic celiac disease. Administration of a gluten-free diet caused a prompt improvement of both hepatic and intestinal biochemical/histologic abnormalities. Hepatic damage may be another "atypical" form of celiac disease in children.

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