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Vaccine. 1993;11(2):119-21.

Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit.

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  • 1Division of Communicable Diseases, St George's Hospital Medical School, London, UK.


Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation index of 20, and was detected up to 1 year later. The proliferative response kinetics suggest the appearance in the blood of primed T cells from the gut coinciding with the disappearance of primed plasmablasts from the circulation, supporting the concept of a common mucosal immune system in man for T and B cells.

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