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Trends Biochem Sci. 1993 Jan;18(1):7-12.

Membrane traffic wardens and protein secretion in gram-negative bacteria.

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  • 1Department of Biological Sciences, University of Warwick, Coventry, UK.


Recent progress in the genetic analysis of protein secretion in diverse Gram-negative bacteria has revealed three major, highly conserved but functionally independent pathways that involve accessory apparatus proteins. Protein secretion via the Type I pathway is signal sequence-independent with no free periplasmic intermediate. Secretion by the Type II pathway is signal sequence-dependent and via the periplasm. Recent results also suggest that a third (Type III) secretory pathway exists in which protein secretion is signal sequence-independent.

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