J Cereb Blood Flow Metab. 1993 Mar;13(2):310-4.

Decrease in human striatal dopamine D2 receptor density with age: a PET study with [11C]raclopride.

Rinne JO, Hietala J, Ruotsalainen U, Säkö E, Laihinen A, Någren K, Lehikoinen P, Oikonen V, Syvälahti E.

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Department of Neurology, University of Turku, Finland.

Abstract

The effect of age on human striatal dopamine D2 receptors was investigated with positron emission tomography (PET) using [11C]raclopride as a radioligand. Twenty-one healthy volunteers aged from 20 to 81 years were studied. An equilibrium method was applied and two separate PET scans with different specific activities of [11C]raclopride were performed. The maximal number of receptors (Bmax) and their dissociation constant (Kd) were calculated using Scatchard analysis. There was an age-dependent decline in the Bmax (r = -0.49; p = 0.02) of striatal D2 receptors while the Kd remained unchanged. The results show that there is an age-related loss of striatal D2 receptors, which, together with other changes in the brain nigrostriatal dopaminergic system, may contribute to extrapyramidal symptoms associated with aging.

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