[Thromboxane A2 receptor; structure, function and ...[Nippon Rinsho. 1993]

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1: Nippon Rinsho. 1993 Jan;51(1):233-40.Links

[Thromboxane A2 receptor; structure, function and tissue distribution]

[Article in Japanese]

Namba T, Narumiya S.

Department of Pharmacology, Faculty of Medicine, Kyoto University.

Thromboxane A2 is an unstable, yet quite potent metabolite of arachidonic acid. Analysis of cDNAs of human and mouse thromboxane A2 receptors revealed important information in regard to the function of thromboxane A2 and its regulation. Examination of amino acid sequences of the receptors provides some information how the ligand binds to the receptor and how desensitization of the receptor occurs. mRNA of the thromboxane A2 receptor is abundantly expressed in the thymus, lung and spleen, and suggests novel function of thromboxane A2. Further progress on understanding of thromboxane A2 and development of effective drugs may be made on the basis of these findings.

PMID: 8433523 [PubMed - indexed for MEDLINE]

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Structure and expression of the murine thromboxane A2 receptor gene. [Biochem Biophys Res Commun. 1999]
Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling. [J Biol Chem. 1996]
Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor. [Arch Biochem Biophys. 2000]
ReviewMolecular mechanisms of diverse actions of prostanoid receptors. [Biochim Biophys Acta. 1995]

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[Thromboxane A2 receptor; structure, function and tissue distribution]

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