Accumulation of adenine and thymine in a groE-homologous operon of an intracellular symbiont

J Mol Evol. 1993 Feb;36(2):121-6. doi: 10.1007/BF00166247.

Abstract

As a result of the nucleotide sequence analysis of an aphid endosymbiont's operon homologous to the Escherichia coli groE, we noted that directional base substitutions tending toward an increase of A + T content represent an obvious evolutionary trend in this prokaryotic operon, housed for a long period by an eukaryotic cell. This result, when taken together with previous reports, raised the possibility that genomic DNA of prokaryotes residing in an eukaryotic cell is subject to A/T-biased directional mutation pressure and/or both negative and positive selection operating under conditions specific to the intracellular environments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / metabolism*
  • Animals
  • Aphids / microbiology
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Base Sequence
  • Biological Evolution
  • Chaperonins*
  • Cloning, Molecular
  • Codon
  • DNA, Bacterial
  • Escherichia coli / genetics
  • Escherichia coli Proteins
  • Gram-Negative Bacteria / genetics*
  • Gram-Negative Bacteria / metabolism
  • Heat-Shock Proteins / genetics*
  • Heat-Shock Proteins / metabolism
  • Molecular Sequence Data
  • Operon*
  • Sequence Homology, Nucleic Acid
  • Symbiosis
  • Thymine / metabolism*

Substances

  • Bacterial Proteins
  • Codon
  • DNA, Bacterial
  • Escherichia coli Proteins
  • GroE protein, E coli
  • Heat-Shock Proteins
  • SymL protein, Bacteria
  • Chaperonins
  • Adenine
  • Thymine