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Arthritis Rheum. 1993 Feb;36(2):263-8.

Prevention of autoimmune inflammatory polyarthritis in male New Zealand black/KN mice by transplantation of bone marrow cells plus bone (stromal cells).

Author information

  • 1First Department of Pathology, Kansai Medical University, Osaka, Japan.

Abstract

OBJECTIVE:

To prevent polyarthritis in male New Zealand black/KN (NZB/KN) mice by transplantation of both bone marrow cells (BMC) and bone (to recruit stromal cells) from normal mice.

METHODS:

Arthritic lesions in male NZB/KN mice injected intravenously with BMC plus bone from C57Bl/10 mice were compared with those in untreated male NZB/KN mice.

RESULTS:

Male NZB/KN mice engrafted with BMC plus bone were both radiologically and histopathologically normal, and had decreased production of anti-single-stranded DNA antibodies and rheumatoid factors at 8-12 months of age.

CONCLUSION:

Bone marrow transplantation prevented polyarthritis in male NZB/KN mice.

PMID:
8431217
[PubMed - indexed for MEDLINE]
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