Oral Surg Oral Med Oral Pathol. 1993 Feb;75(2):156-64.

Comparison of oral triazolam and nitrous oxide with placebo and intravenous diazepam for outpatient premedication.

Source

Clinical Pharmacology Unit, National Institute for Dental Research, National Institutes of Health, Bethesda, Md.

Abstract

Triazolam was evaluated as an oral sedative agent for dental outpatients in two studies in the oral surgery model. The first study demonstrated that 0.25 mg of triazolam in combination with nitrous oxide provides therapeutic effects but with a more rapid recovery than a 0.50 mg dose in combination with nitrous oxide. In the second study, triazolam produced a significant anxiolytic effect that was comparable to the effects of diazepam titrated to the usual clinical endpoint (mean dose = 19.3 mg). Less impairment in cognitive-psychomotor impairment and ambulatory function was seen after triazolam in comparison with diazepam. Triazolam appears to be a safe, effective alternative to parenteral sedation with a benzodiazepine for dental outpatients.

PMID:: 8426714; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Medical

Anxiety - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Related citations

Comparison of triazolam, diazepam, and placebo as outpatient oral premedication for endodontic patients. [J Endod. 1997]
Comparison of triazolam, diazepam, and placebo as outpatient oral premedication for endodontic patients.
Ehrich DG, Lundgren JP, Dionne RA, Nicoll BK, Hutter JW. J Endod. 1997 Mar; 23(3):181-4.
Comparison of sublingually and orally administered triazolam for premedication before oral surgery. [Oral Surg Oral Med Oral Pathol Oral Radiol ...]
Comparison of sublingually and orally administered triazolam for premedication before oral surgery.
Berthold CW, Dionne RA, Corey SE. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Aug; 84(2):119-24.
Oral triazolam pretreatment for intravenous sedation. [Anesth Prog. 1993]
Oral triazolam pretreatment for intravenous sedation.
Stopperich PS, Moore PA, Finder RL, McGirl BE, Weyant RJ. Anesth Prog. 1993; 40(4):117-21.
Review Using triazolam to reduce dental anxiety. [J Am Dent Assoc. 1993]
Review Using triazolam to reduce dental anxiety.
Berthold CW, Schneider A, Dionne RA. J Am Dent Assoc. 1993 Nov; 124(11):58-64.
Review Enteral sedation: safety, efficacy, and controversy. [Compend Contin Educ Dent. 2007]
Review Enteral sedation: safety, efficacy, and controversy.
Berthold C. Compend Contin Educ Dent. 2007 May; 28(5):264-71; quiz 272, 282.

See reviews... See all...

Cited by 3 PubMed Central articles

Zaleplon (Sonata) oral sedation for outpatient third molar extraction surgery. [Anesth Prog. 2005]
Zaleplon (Sonata) oral sedation for outpatient third molar extraction surgery.
Ganzberg SI, Dietrich T, Valerin M, Beck FM. Anesth Prog. 2005 Winter; 52(4):128-31.
The efficacy and memory effects of oral triazolam premedication in highly anxious dental patients. [Anesth Prog. 1994]
The efficacy and memory effects of oral triazolam premedication in highly anxious dental patients.
Milgrom P, Quarnstrom FC, Longley A, Libed E. Anesth Prog. 1994; 41(3):70-6.
Summary of the scientific literature for pain and anxiety control in dentistry. [Anesth Prog. 1994]
Summary of the scientific literature for pain and anxiety control in dentistry.
Hassett LC. Anesth Prog. 1994; 41(2):48-57.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Comparison of oral triazolam and nitrous oxide with placebo and intravenous diaz...
Comparison of oral triazolam and nitrous oxide with placebo and intravenous diazepam for outpatient premedication.
Oral Surg Oral Med Oral Pathol. 1993 Feb ;75(2):156-64.

PubMed
LOC100068030 [Equus caballus]
LOC100068030 [Equus caballus]
Gene ID:100068030

Gene
Failure of fertilization following abbreviated copulation in the ferret (Mustela...
Failure of fertilization following abbreviated copulation in the ferret (Mustela putorius furo).
J Exp Zool. 1989 Jan ;249(1):85-9.

PubMed
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound c...
Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation.
Proc Natl Acad Sci U S A. 1997 Nov 11 ;94(23):12291-6.

PubMed
Attitudes of German persons at risk for Huntington's disease toward predictive a...
Attitudes of German persons at risk for Huntington's disease toward predictive and prenatal testing.
Genet Couns. 1996 ;7(4):303-11.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Comparison of oral triazolam and nitrous oxide with placebo and intravenous diazepam for outpatient premedication.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information