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Neurology. 1993 Jan;43(1):103-6.

A controlled trial with vasopressin analogue (DGAVP) on cognitive recovery immediately after head trauma.

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  • 1Department of Neuropsychology and Psychobiology, University of Limburg, Maastricht, The Netherlands.


Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, matched-pairs study. DGAVP did not have a positive effect on cognitive recovery in this group of mildly affected patients.

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