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Nature. 1993 Jan 7;361(6407):31-9.

A synaptic model of memory: long-term potentiation in the hippocampus.

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  • 1Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK.

Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood form of long-term potentiation is induced by the activation of the N-methyl-D-aspartate receptor complex. This subtype of glutamate receptor endows long-term potentiation with Hebbian characteristics, and allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and postsynaptic mechanisms to generate a persistent increase in synaptic strength.

PMID:
8421494
[PubMed - indexed for MEDLINE]
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