Immunogenetics. 1993;37(3):193-8.

Isolation of a novel cDNA clone showing marked similarity to ME491/CD63 superfamily.

Emi N, Kitaori K, Seto M, Ueda R, Saito H, Takahashi T.

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First Department of Internal Medicine, Nagoya University School of Medicine, Japan.

Abstract

A novel cDNA clone, A15, was isolated by the differential screening of a cDNA library of an immature T cell line, HPB-ALL using radioactive cDNA probes from the mRNA of either HPB-ALL or peripheral blood lymphocytes. It hybridized to a single mRNA species of about 2.0 kilobases which is expressed in HPB-ALL cell line, but not in the PBL or a promyelocytic leukemia cell line, HL-60. The A15 gene codes for a protein of 244 amino acids which contains four potential transmembrane domains and four possible N-linked glycosylation sites. A computer-aided comparison showed a marked similarity to several other membrane proteins: CD9, CD37, CD53, TAPA-1, Sm23, CO-029, and ME491/CD63.

PMID:: 8420826; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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GENBANK/D10653

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Immunogenetics. 1993 ;37(3):193-8.

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