Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Med. 1993 Jan;94(1):62-8.

Vitamin K and maintenance of skeletal integrity in adults.

Author information

  • 1Charles A. Dana Research Institute, Boston, Massachusetts.

Abstract

PURPOSE:

To determine the role of vitamin K status in the maintenance of skeletal integrity in adults.

PATIENTS AND METHODS:

1. Bone mineral density (BMD) was measured by quantitative digital radiography (QDR) in 50 patients taking a vitamin K antagonist (warfarin) who were recruited from a large urban cardiology practice, and 50 age-, sex- and race-matched controls recruited from the community. 2. The relationship of BMD versus indices of vitamin K status (determined by measuring levels of vitamin K and descarboxyprothrombin in the plasma) in 113 nonanticoagulated adults was assessed.

RESULTS:

Measurements of BMD in the hip and spine were similar in anticoagulated subjects and matched controls. Multivariate analysis revealed that use of warfarin was not associated with a lower BMD. Ninety-five percent confidence intervals excluded a 0.06 g/cm2 reduction in BMD associated with the use of warfarin. Indices of vitamin K status did not correlate with BMD in normal subjects.

CONCLUSIONS:

Patients receiving long-term maintenance therapy with a vitamin K antagonist have normal bone density. BMD is unrelated to vitamin K status in nonanticoagulated subjects. These data suggest that vitamin K does not have a major role in maintenance of skeletal integrity in adults.

PMID:
8420301
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk