J Pediatr. 1993 Jan;122(1):100-3.

Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency.

Bhala A, Bennett MJ, McGowan KL, Hale DE.

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Department of Pediatrics and Pathology, University of Pennsylvania School of Medicine, Philadelphia.

Abstract

Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylpropionylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.

PMID:: 8419594; [PubMed - indexed for MEDLINE]

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Chemical compound information

3-phenylpropionylglycine

MW: 207.22 g/mol

MF: C₁₁H₁₃NO₃

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